Los Angeles Chargers at Carolina Panthers: Predictions, picks and odds for NFL Week 2 game

Los Angeles Chargers at Carolina Panthers: Predictions, picks and odds for NFL Week 2 game

September 11, 2024

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A rare interconference matchup is on deck in Charlotte for the Carolina Panthers (0-1) home opener against the Los Angeles Chargers (1-0).

The Jim Harbaugh era in Los Angeles is off to a victorious after the Chargers defeated the Las Vegas Raiders in Week 1. The defense was stout and even though the offense wasn’t thunderous, J.K. Dobbins had a breakout game that should given the unit a spark and Justin Herbert a solid weapon.

It’s tough to find anyone that had a tougher first week of the season than the Panthers, who were straight up ripped apart by the New Orleans Saints in a game that was never a contest. There was hope Bryce Young could take a big leap in 2024, and he’ll have a chance to change the negative narrative surrounding him against another tough defense.

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Panthers vs. Chargers odds, moneyline, over/under

The Chargers are favorites to defeat the Panthers, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

  • Spread: Chargers (-6.5)
  • Moneyline: Chargers (-275); Panthers (+220)
  • Over/under: 39

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NFL Week 2 odds, predictions and picks

Dolphins vs. Bills | Ravens vs. Raiders | Panthers vs. Chargers | Cowboys vs. Saints | Lions vs. Buccaneers | Packers vs. Colts | Jaguars vs. Browns | Vikings vs. 49ers | Patriots vs. Seahawks | Titans vs. Jets | Commanders vs. Giants | Cardinals vs. Rams | Chiefs vs. Bengals | Broncos vs. Steelers | Texans vs. Bears | Eagles vs. Falcons

Lorenzo Reyes: Chargers 29, Panthers 12 

I just don’t trust the Panthers to cover anything less than a touchdown. Carolina has too many holes on its roster, a leaky offensive line and Bryce Young should struggle against a diverse and complex defense. I think the Chargers cruise.

Tyler Dragon: Chargers 24, Panthers 16

Jim Harbaugh got his first win as a Chargers head coach in Week 1. Los Angeles performed much differently with Harbaugh at the helm – stout defense and a solid running game. The Panthers were listless in their opener and have a lot of work to do. Bryce Young is still developing, but you’d like to see market improvement from Year 1 to Year 2. The Chargers haven’t started a season 2-0 since 2012.

Richard Morin: Chargers 22, Panthers 12

The Chargers’ offense might be sleepy with an early start, but they still have plenty to take care of the lowly Panthers. The under is pretty low, but I might still go for it.

Jordan Mendoza: Chargers 17, Panthers 9

If you watch football for offense, this isn’t the game for you. Jim Harbaugh has no problem with his defense ruling the day while his offense is still trying to figure itself out, and Carolina just isn’t there yet when it comes to showing it’s an improved team. The Chargers have only beaten the Panthers once, back in 2004, and they get their second victory on Sunday. This is a good candidate to hit the under.

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