Jacksonville Jaguars at Buffalo Bills: Predictions, picks and odds for NFL Week 3 game

Jacksonville Jaguars at Buffalo Bills: Predictions, picks and odds for NFL Week 3 game

September 18, 2024

play

(This story was updated to add new information.)

Two AFC teams headed in opposite directions will meet on “Monday Night Football” when the Buffalo Bills (2-0) host the Jacksonville Jaguars (0-2).

It’s been a frustrating start offensively for Trevor Lawrence and company, with the latest example coming in a loss to a Cleveland Browns team that was just embarrassed by the Dallas Cowboys. Now going back to last season, Jacksonville has lost seven of its last eight games and badly needs a victory to remain in the hunt for a division title.

Buffalo lost so much from last season but the success remains. The Bills defeated the Dolphins in every facet of the game on “Thursday Night Football” and are riding solid momentum to another AFC East title.

PROP TALK: These are the best prop bets for NFL games this week 

Bills vs. Jaguars odds, moneyline, over/under

The Bills are favorites to defeat the Jaguars, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

  • Spread: Bills (-5.5)
  • Moneyline: Bills (-250); Jaguars (+200)
  • Over/under: 45.5

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.

FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week 

Bet on NFL with BetMGM

NFL Week 3 odds, predictions and picks

Jets vs. Patriots | Browns vs. Giants | Colts vs. Bears | Vikings vs. Texans | Saints vs. Eagles | Steelers vs. Chargers | Buccaneers vs. Broncos | Titans vs. Packers | Raiders vs. Panthers | Seahawks vs. Dolphins | Cardinals vs. Lions | Cowboys vs. Ravens | Rams vs. 49ers | Falcons vs. Chiefs | Bills vs. Jaguars | Bengals vs. Commanders

Lorenzo Reyes: Bills 29, Jaguars 19

The Jaguars simply have not shown very much to start this season to give you any optimism. Trevor Lawrence isn’t producing as he should. Doug Pederson has had some questionable game management issues. And the Bills look like a formidable force in the AFC once again, even with some of their offseason departures.

Tyler Dragon: Bills 25, Jaguars 24

The new-look Bills are winning with a balanced offensive attack and Josh Allen is taking care of the football. Jacksonville’s underachieved to start the season. Now the Jags have two straight road games against tough opponents. The Jaguars are in serious danger of starting the year 0-4. Things might go south quickly for the AFC South team.

Richard Morin: Jaguars 24, Bills 23

Trevor Lawrence and the Jaguars need a win, and they’ll get a big one over a top AFC contender on the road. 

Jordan Mendoza: Bills 30, Jaguars 20

Jacksonville is in a funk and while they should eventually shake it off, it’ll be tough to do it in front of the raucous Bills mafia in primetime. James Cook has solidified himself as a star and he has another big game to help out Josh Allen.

MOST VALUABLE BET: Who is the favorite to win NFL MVP in 2024?