Buffalo Bills at Indianapolis Colts: Predictions, picks and odds for NFL Week 10 game

Buffalo Bills at Indianapolis Colts: Predictions, picks and odds for NFL Week 10 game

November 6, 2024

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The Buffalo Bills (7-2) are rolling, and they can inch closer toward a division title when they visit the Indianapolis Colts (4-5) on Sunday.

The leg of Tyler Bass kept the winning streak alive for Buffalo as the team has completely separated themselves from the rest of the AFC East. The Bills lead the division by more than three games, and they could theoretically lock it up before the end of the month. That goal can become possible with another win.

Joe Flacco couldn’t bring any magic when he stepped in as the starting quarterback for Indianapolis, with the offense failing to get in the endzone in the Sunday night loss to Minnesota. The Colts will expect he can turn the page when they go up against one of the best-scoring defenses in the league.

PROP TALK: These are the best prop bets for NFL games this week 

Colts vs. Bills odds, moneyline, over/under

The Bills are favorites to defeat the Colts, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

  • Spread: Bills (-4)
  • Moneyline: Bills (-210); Colts (+170)
  • Over/under: 46

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NFL Week 10 odds, predictions and picks

Ravens vs. Bengals | Panthers vs. Giants | Bears vs. Patriots | Colts vs. Bills | Jaguars vs. Vikings | Chiefs vs. Broncos | Saints vs. Falcons | Buccaneers vs. 49ers | Commanders vs. Steelers | Chargers vs. Titans | Cardinals vs. Jets | Cowboys vs. Eagles | Texans vs. Lions | Rams vs. Dolphins

Lorenzo Reyes: Bills 28, Colts 17

The Colts have mismanaged their quarterback situation and Indianapolis has become one-dimensional without the rushing threat that Anthony Richardson brings. The Bills’ defense has its weaknesses, but Buffalo should be able to outscore the Colts with relative ease.

Tyler Dragon: Bills 28, Colts 18

I don’t agree with Anthony Richardson’s demotion. The Colts made a hasty decision to Richardson, who is a talented quarterback but needs time to develop. The Bills are trying to win the AFC East. They currently have a four-game lead.

Richard Morin: Bills 33, Colts 10

The Colts are quickly losing ground and have created a mess for themselves at the quarterback situation. The Bills, meanwhile, are striding along toward a high playoff seed

Jordan Mendoza: Bills 31, Colts 23

The Bills have been one of the best scoring offenses in the league while Indianapolis has had trouble in stopping teams from moving the ball. As long as Buffalo plays a clean game, this should be an easy one for a fifth-straight win.