Admin October 2, 2024
NFL Overreactions Week 4
Mackenzie Salmon breaks down some of the biggest games from NFL week 4.
Sports Seriously
The San Francisco 49ers (2-2) have had success at home this season, and the next chance to keep it going will be Week 5 against the Arizona Cardinals (1-3).
The Cardinals are the latest team to find out how sensational Jayden Daniels is when Washington came in and torched Arizona in its own stadium. The offense that exploded in Week 2 has struggled since, and it will have to try to and reignite the spark against a tough defense.
Coming off back-to-back head-scratching losses, the 49ers regrouped by destroying the New England Patriots in a much-needed victory. Luckily, the reigning division champions have another chance to assert dominance and get on the path back to the top.
PROP TALK: These are the best prop bets for NFL games this week
49ers vs. Cardinals odds, moneyline, over/under
The 49ers are favorites to defeat the Cardinals, according to BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.
- Spread: 49ers (-7.5)
- Moneyline: 49ers (-350); Cardinals (+280)
- Over/under: 50
Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.
New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.
FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week
NFL Week 5 odds, predictions and picks
Falcons vs. Buccaneers | Vikings vs. Jets | Bears vs. Panthers | Bengals vs. Ravens | Texans vs. Bills | Jaguars vs. Colts | Patriots vs. Dolphins | Commanders vs. Browns | Broncos vs. Raiders | 49ers vs. Cardinals | Rams vs. Packers | Seahawks vs. Giants | Steelers vs. Cowboys | Chiefs vs. Saints
Lorenzo Reyes: 49ers 30, Cardinals 10
This is an interesting spot because the Cardinals, under Jonathan Gannon, have actually gotten up for games against some of the best teams in the league, pulling off upsets. Still, the Niners beat Arizona last year by an average of 17.5 points per game. San Francisco’s defense remains a concern, but the Cardinals are too inconsistent and nowhere near as deep.
Tyler Dragon: 49ers 26, Cardinals 20
San Francisco got back on track in Week 4. Brock Purdy is second in the NFL in passing yards and Jordan Mason is second in the league in rushing yards. Fred Warner’s ankle injury is a concern. The 49ers have won four straight games versus Arizona.
Jordan Mendoza: 49ers 34, Cardinals 15
San Francisco needed to flex its muscle against the Patriots, and it needs to do the same to the Cardinals. Arizona has lost to the 49ers by an average of 22 points in the last four meetings.
MOST VALUABLE BET: Who is the favorite to win NFL MVP in 2024?