Patriots at Bills: Predictions, picks, odds for NFL Week 16 game

Patriots at Bills: Predictions, picks, odds for NFL Week 16 game

December 18, 2024

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On paper, the matchup between the New England Patriots (3-11) and the Buffalo Bills (11-3) shouldn’t be close. But this is the NFL, and anything can happen on Sundays.

The losing streak in New England has reached four games, with the latest coming against Arizona. The Patriots didn’t do much until it was too late, and at the moment it’s tough to imagine them getting another win this season. Still, there’s hope for progress heading into next season.

Josh Allen continues to dominate anything that gets in his way, and he had one of his most impressive games yet when he led Buffalo to a convincing win over the Detroit Lions. It seems like there’s no way to stop the Bills offense right now, and it’s a reason why they are Super Bowl favorites. After putting up 40 points in back-to-back weeks, can Buffalo do it again?

Bills vs. Patriots odds, moneyline, over/under

The Bills are favorites to defeat the Patriots, according to the BetMGM NFL odds. Not interested in this game? Check out expert picks and best bets for every NFL game this week.

  • Spread: Bills (-14)
  • Moneyline: Bills (-1000); Patriots (+650)
  • Over/under: 46.5

NFL Week 16 odds, predictions and picks

Chargers vs. Broncos | Chiefs vs. Texans | Ravens vs. Steelers | Bengals vs. Browns | Falcons vs. Giants | Bills vs. Patriots | Panthers vs. Cardinals | Bears vs. Lions | Colts vs. Titans | Jets vs. Rams | Commanders vs. Eagles | Seahawks vs. Vikings | Raiders vs. Jaguars | Dolphins vs. 49ers | Cowboys vs. Buccaneers | Packers vs. Saints

Tyler Dragon: Bills 31, Patriots 16

The Bills rebounded nicely in Week 15 after an upset loss to the Rams. This is a game that Josh Allen can pad his MVP numbers.

Jordan Mendoza: Bills 38, Patriots 10

The only real question will be how many times Buffalo punts the ball. Other than that, this game shouldn’t be much of a contest.