Indianapolis Colts at Jacksonville Jaguars: Predictions, picks and odds for NFL Week 5 game

Indianapolis Colts at Jacksonville Jaguars: Predictions, picks and odds for NFL Week 5 game

October 2, 2024

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Through four weeks, the only winless team in the NFL is the Jacksonville Jaguars. Despite the emergence of first-round receiver Brian Thomas Jr., the Jaguars have failed to earn a single victory. They came close in Week 4, nearly upsetting the Houston Texans, but after a late touchdown sealed it for Houston, the Jaguars left NRG Stadium dejected.

The Indianapolis Colts have had the opposite issue. After an 0-2 start, Indianapolis has won two consecutive games, including a victory over the previously undefeated Pittsburgh Steelers. After starting quarterback Anthony Richardson left the game with a hip injury, backup Joe Flacco stepped in and arguably elevated the passing attack to help Indy secure its second win. He was a tremendous breath of fresh air for Cleveland a year ago. Can he recapture some of that magic for the Colts in 2024 should Richardson be unable to play on Sunday?

Here are our experts’ predictions for this AFC South matchup.

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Jaguars vs. Colts odds, moneyline, over/under

The Jaguars are favorites to defeat the Colts, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

  • Spread: Jaguars (-3)
  • Moneyline: Jaguars (-150); Colts (+125)
  • Over/under: 46

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NFL Week 5 odds, predictions and picks

Falcons vs. Buccaneers | Vikings vs. Jets | Bears vs. Panthers | Bengals vs. Ravens | Texans vs. Bills | Jaguars vs. Colts | Patriots vs. Dolphins | Commanders vs. Browns | Broncos vs. Raiders | 49ers vs. Cardinals | Rams vs. Packers | Seahawks vs. Giants | Steelers vs. Cowboys | Chiefs vs. Saints

Lorenzo Reyes: Colts 24, Jaguars 17

You should wait until later in the week to get clarity on the Colts’ quarterback situation. Either way, I actually think Joe Flacco can be a stabilizing presence for Indy. The Jaguars, meanwhile, can wear their throwback uniforms all they want, this team has massive holes and Trevor Lawrence’s confidence appears to be shaky.

Tyler Dragon: Jaguars 21, Colts 20

Jaguars coach Doug Pederson took a veiled shot at his players after the team’s 0-4 start. Will Pederson’s words motivate the team or lose the locker room? The coach is on the hot seat. But I think Jacksonville finally gets a win this week at home.

Jordan Mendoza: Jaguars 23, Colts 21

The record is bad, but Jacksonville has had a tough schedule to start the season. The Jaguars finally put it together to get a victory.

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