Jacksonville Jaguars at Buffalo Bills: Predictions and odds for NFL Week 3

Jacksonville Jaguars at Buffalo Bills: Predictions and odds for NFL Week 3

September 22, 2024

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The Buffalo Bills will host the Jacksonville Jaguars for the first game of a Monday Night Football doubleheader to conclude Week 3 of the season.

The Bills (2-0) are coming off a convincing 31-10 victory on the road against the Miami Dolphins last week. Running back James Cook had 11 carries for 78 yards and two touchdowns in the victory.

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The Jaguars (0-2) are coming off a pair of close losses to start the season. Quarterback Trevor Lawrence has competed 26 of 51 pass attempts for 382 yards and a touchdown through the first two weeks. He has also been sacked seven times.

Jacksonville will play a game on Monday for a second consecutive year, having played in a 34-31 overtime loss to the Cincinnati Bengals last season. Before 2023, the Jaguars had not played on MNF since 2011.

Here’s what to know about the Jaguars-Bills Week 3 matchup on Monday:

Jaguars vs. Bills odds, moneyline, over/under

Buffalo is favored to start the season with a win, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

Odds as of Sunday

  • Spread: Bills (-5.5)
  • Moneyline: Bills (-250); Jaguars (+200)
  • Over/under: 45.5

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Jaguars vs. Bills predictions

JaguarsWire: Bills 28, Jaguars 24

Zach Goodall writes “The Jaguars’ offense will appear in rhythm, particularly the rushing attack with Travis Etienne Jr. and Tank Bigsby each having a productive night. But the Bills’ rushing attack will be similarly effective if not more, headlined by emerging star running back James Cook and the ever-dynamic Josh Allen, leading Buffalo to pull off the victory.”

Sports Illustrated: Bills 31, Jaguars 14

Hans A. Hansen lll writes “Buffalo has a massive advantage on the offensive side of the ball with its passing attack poised to break out against a weak and underwhelming Jaguars secondary. Buffalo wins in blowout fashion heading into a massive Sunday night game against the Ravens next week.”

BigAl’s: Bills 31, Jaguars 21

Rod Pearson writes “The Jaguars just haven’t looked right on offense in their 2 games and this game isn’t going to be any easier on the road in Buffalo against this new-look Bills team. The Bills are rolling right now on both offense and defense while the Jaguars are still trying to figure things out this year and get into a rhythm on the field, something they haven’t really been able to find.”

Sporting News: Bills 24, Jaguars 17

Vinnie Iyer writes “The Bills have looked fantastic in two games with Josh Allen in total control of a more efficient, run-heavy offense and diverse passing game under Joe Brady. Their defensive weakness lies vs. the run and the middle of the field in coverage, but with the way Trevor Lawrence is looking too much downfield, they can put good pressure on him on the road. Meanwhile, Allen will get to flex his deep arm more often vs. an overwhelmed secondary.”